Aug 2, 2023 · Soluble epoxide hydrolase (sEH) is expressed in both peripheral tissues and CNS. Its upregulation has been implicated in multiple neurological conditions, including depression, . Dec 15, 2020 · Given that epoxide hydrolase inhibitors are already being tested in the clinic for other conditions, they may have the potential to become a new class of AD drug. Darryl Zeldin, National . Gregory A, Tang C, Fan F. Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias. Neural Regen Res. 2025 Sep 1;20 (9):2585-2586.
Dec 15, 2020 · Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27;8 (1):5279. PubMed. O'Brien CE, Santos PT, Kulikowicz E, Lee JK, . Lee HT, Lee KI, Chen CH, Lee TS. Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16 (1):267. PubMed. Aug 2, 2023 · But what if targeting a peripheral enzyme could do the job? In the June 26 Neuron online, researchers led by Xin-Hong Zhu at Shenzhen University, China, reported that inhibiting a liver .
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Mar 6, 2025 · Alzheimer’s may be, at least in part, a disease of the immune system. Evidence supporting this comes from the study of genetics, infectious diseases, and the molecular machinations of the .
- Soluble epoxide hydrolase (sEH) is expressed in both peripheral tissues and CNS.
- Epoxide Hydrolase, a Fat New Target for Alzheimer’s Therapy?.
- Given that epoxide hydrolase inhibitors are already being tested in the clinic for other conditions, they may have the potential to become a new class of AD drug.
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse. This indicates that "epoxide and thiol epoxy chemistry" should be tracked with broader context and ongoing updates.
Genetic deletion of soluble epoxide hydrolase delays the progression. For readers, this helps frame potential impact and what to watch next.
FAQ
What happened with epoxide and thiol epoxy chemistry?
Recent reporting around epoxide and thiol epoxy chemistry points to new developments relevant to readers.
Why is epoxide and thiol epoxy chemistry important right now?
It matters because it may affect decisions, expectations, or near-term outcomes.
What should readers monitor next?
Watch for official updates, verified data changes, and follow-up statements from primary sources.
Sources
- https://www.alzforum.org/papers/hepatic-soluble-epoxide-hydrolase-activity-regulates-cerebral-av-metabolism-and-pathogenesis
- https://www.alzforum.org/news/research-news/epoxide-hydrolase-fat-new-target-alzheimers-therapy
- https://www.alzforum.org/papers/soluble-epoxide-hydrolase-next-generation-drug-target-alzheimers-disease-and-related
- https://www.alzforum.org/papers/epoxide-hydrolase-inhibitor-reduces-neuroinflammation-mouse-model-alzheimers-disease
